{
  "ground_id": "archive-HER2-case5_20260415130231",
  "problem_queries": [
    "HER2 breast cancer deep learning multimodal pathology",
    "immunohistochemistry AI automated scoring HER2",
    "missing modality in multimodal deep learning medical imaging",
    "H&E histopathology molecular biomarker prediction from histology",
    "HER2-low breast cancer diagnostic challenges AI"
  ],
  "method_queries": [
    "cross-modal image synthesis histopathology GAN Pix2Pix",
    "shared-specific feature modeling multimodal learning missing modality",
    "channel attention adaptive multimodal fusion medical imaging",
    "missing modality branch selection dynamic deep learning",
    "H&E to immunohistochemistry image translation breast cancer"
  ],
  "constraint_queries": [
    "histopathology deep learning domain generalization cross-institution",
    "clinical validation AI HER2 pathology deployment challenges",
    "generated synthetic medical images pathologist accuracy evaluation",
    "computational pathology external dataset validation gap"
  ]
}